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(SA). Patients with ovarian clear cell adenocarcinoma are typically above the age of 30 with a median of 54 which is similar to that of ovarian epithelial cancer in general. Although the tumor markers have a low specificity and sensitivity, they are often used in screening for ovarian cancer. It is controversial as to whether overexpression of the HER-2/neu gene in ovarian cancer is associated with poor prognosis. If postoperative radiation is prescribed for a patient, it is important that theentire abdomen and pelvis are optimally treated to elicit a response from the tumor (Sharp, 278-280). However, it has only been within the last ten years that a firm basis for this method of drug delivery has become established. Etiology It is commonly accepted that cancer results from a series of genetic alterations that disrupt normal cellular growth and differentiation.
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Mutations in host tumor suppresser gene p53 are found in 50 of ovarian carcinomas. Cytogenetic investigations of sporadic (non-inherited) ovarian tumors have revealed frequent alterations of chromosomes 1,3,6, and. The drugs used in ovarian cancer tend to have fewer side effects, and thus are easier to tolerate than many other chemotherapy drugs. That means that stages IIB and IIC and stages iiia and IIB are the only true indications for extrapelvic cytoreductive surgery. Considerable variation exists in the gross appearance of ovarian clear cell adenocarcinomas and they are generally indistinguishable from other epithelial ovarian carcinomas. Similar problems have been found in attempted grading of clear cell adenocarcinoma of the endometrium (Disaia, 176). Ovary Cancer Resource Center. Some women even decide to remove both ovaries, which can increase the chance of osteoporosis, because the ovaries produce estrogen, which fights osteoporosis. Olaparib (Lynparza) and niraparib (Zejula) are parp inhibitors that may be used to treat advanced ovarian cancer. By that time it is no longer an early but rather a biologically late tumor (Altchek, 292). Since talcum powders are no longer contaminated with asbestos, the risk is probably no longer important (Barber, 200). Radiation techniques include intraperitoneal radioactive gold or chromium phosphate and external beam therapy to the abdomen and pelvis.
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